MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 42503445.
- Also identified by DOI 10.1002/lary.70749.
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Abstract
An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.