Molecular velcro for precision genome repair.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42521680.
- Also identified by DOI 10.1038/s41467-026-76136-9 and PMC identifier 13415851.
- Licence recorded as CC BY-NC-ND.
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Abstract
Base editing promises transformative therapies for genetic disease, but delivery constraints have limited clinical translation. Mu and colleagues show that programmable coiled-coil assembly can create highly efficient split base editors and demonstrate its in vivo functionality.