Neural architecture as cancer's safe harbor.
Where this comes from
- Record sourced from PubMed, PMID 42525785.
- Also identified by DOI 10.1126/scitranslmed.aeg3160.
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Abstract
Targeting peripheral nerves improves antitumor immunity despite overlapping molecular expression in neurons and tumor stroma. This advantage may be due to preexisting innervation establishing spatially restricted signaling zones that favor immune suppression early in transformation. This framework suggests potential therapeutic opportunities by disrupting neural architecture rather than blocking individual mediators.
Medical subject headings
- Neoplasms