FDG PET/CT in a Case of α-Fetoprotein-Producing Urothelial Carcinoma With Hepatoid Differentiation of the Renal Pelvis.

Man, Xiaojun; Dong, Changming; Dong, Aisheng; Song, Xiandong · Clin Nucl Med · 2026

case_report · Level V

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Abstract

An α-fetoprotein-producing tumor in the urinary tract is rare. We describe FDG PET/CT findings in a case of α-fetoprotein-producing urothelial carcinoma with hepatoid differentiation of the left renal pelvis with a significantly elevated serum α-fetoprotein level (1035 ng/mL). FDG PET/CT showed intense activity of the left renal pelvic tumor with invasion of the renal parenchyma. This case indicates that α-fetoprotein-producing urothelial carcinoma with hepatoid differentiation should be considered in the differential diagnosis of FDG-avid tumors of the urinary tract in patients with elevated serum α-fetoprotein levels.

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