Pediatric Synchronous Nasopharyngeal Carcinoma Mimicking Refractory Hodgkin Lymphoma.
case_report · Level V
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- Record sourced from PubMed, PMID 42530283.
- Also identified by DOI 10.1097/RLU.0000000000006638.
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Abstract
A 12-year-old girl with a 5-month history of painless left neck swelling was diagnosed with nodular sclerosis classic Hodgkin lymphoma, stage II, on baseline histopathology and F-18 FDG PET-CT, respectively. Interim PET-CT showed partial metabolic response (Deauville 4); however, end-of-treatment PET-CT revealed increased uptake in the nasopharynx, left parapharyngeal, and submandibular lymph nodes (Deauville 5). A repeat biopsy showed undifferentiated nasopharyngeal carcinoma (NPC). As NPC is a rare malignancy in the pediatric population, additional stains were also performed on the baseline specimen, which confirmed metastatic NPC coexisting with CHL. The patient was then started on cisplatin-based chemoradiation.