68 Ga-Pentixafor PET/CT as a Noninvasive Alternative in Evaluation of Suspected Aldosterone-producing Adenoma.
case_report · Level V
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- Record sourced from PubMed, PMID 42544987.
- Also identified by DOI 10.1097/RLU.0000000000006614.
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Abstract
A 54-year-old woman with recurrent hypertensive crises was found to have a lipid-rich right adrenal adenoma. Biochemical evaluation was inconclusive for both pheochromocytoma and primary aldosteronism (PA). While 68 Ga-DOTATATE PET/CT showed no abnormal uptake in the adrenal adenoma, effectively excluding pheochromocytoma, 68 Ga-Pentixafor PET/CT demonstrated focal uptake within the adenoma, suggesting an aldosterone-producing adenoma. Given the high clinical suspicion for PA and the invasive nature of adrenal vein sampling, medical therapy with spironolactone was initiated and resulted in a favorable clinical response. This case highlights the potential diagnostic value of CXCR4-targeted PET/CT in suspected PA.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Peptides, Cyclic
- Aldosterone
- Polyvinyls
- Adenoma
- Adrenal Gland Neoplasms
- Coordination Complexes