Decoding neural signals to build metabolic therapies.

Pers, Tune H; Alhadeff, Amber L; Myers, Martin G; Adriaenssens, Alice E; Fenselau, Henning; Stanley, Sarah A; Mansuy-Aubert, Virginie; Domingos, Ana I et al. · Cell Metab · 2026

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Abstract

Ongoing research points to neural circuits as the major targets for the incretin-mimetic drugs that are transforming obesity treatment. In this Voices piece, we asked researchers to discuss their work on how central and peripheral pathways influence energy balance and metabolism, and what next steps are needed to therapeutically target these pathways.

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