Methionine tuning for health without frailty.
Where this comes from
- Record sourced from PubMed, PMID 42551409.
- Also identified by DOI 10.1016/j.cmet.2026.06.013.
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Abstract
Dietary protein quality, not merely quantity, shapes metabolic health and aging trajectories. Fanti et al. show that moderate methionine supplementation to a low-protein, Mediterranean-inspired diet activates a GH-GLP-1-FGF21 axis that reduces adiposity and frailty without caloric restriction; their findings provide a mechanism for why traditional plant-rich diets may promote longevity while sometimes compromising physical robustness.
Medical subject headings
- Methionine
- Frailty