A mitochondrial antioxidant axis fuels iron addiction in colorectal cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42551410.
- Also identified by DOI 10.1016/j.cmet.2026.06.011.
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Abstract
Colorectal cancer (CRC) cells accumulate iron to fuel proliferation yet paradoxically resist its toxicity. Jain et al. reveal that heme stabilizes succinate dehydrogenase subunit C, sustaining complex II-dependent coenzyme Q reduction and its redistribution to the plasma membrane, enabling CRC cells to buffer oxidative stress and iron-induced cell death.
Medical subject headings
- Iron
- Colorectal Neoplasms
- Mitochondria
- Antioxidants