Microglia go beyond surveillance to fuel neuronal protein synthesis on demand.
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- Record sourced from PubMed, PMID 42551411.
- Also identified by DOI 10.1016/j.cmet.2026.05.013.
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Abstract
In this issue of Cell Metabolism, Adler et al.<sup>1</sup> demonstrate that microglia coordinate multicellular metabolic interactions within the neurovascular niche. They identify microglia-derived cysteine-rich angiogenic inducer 61 (CYR61) as a mediator promoting cerebral glucose uptake and neuronal protein synthesis, thereby highlighting a role for microglia in supporting neuronal adaptation on demand.
Medical subject headings
- Microglia
- Neurons
- Protein Biosynthesis