When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42551412.
- Also identified by DOI 10.1016/j.cmet.2026.05.007.
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Abstract
Metabolic dysfunction is a defining but poorly understood feature of Alzheimer's disease. Du et al. show that a brain-penetrant GLP-1 receptor agonist rewires astrocyte-neuron metabolic coupling through lactate-driven histone lactylation, linking astrocytic glycolysis to neuronal lipid homeostasis and positioning metabolite signaling as a therapeutic axis in neurodegeneration.
Medical subject headings
- Astrocytes
- Alzheimer Disease
- Neurons
- Lactic Acid