Weight-loss-independent actions of GLP-1 medicines.
Where this comes from
- Record sourced from PubMed, PMID 42551415.
- Also identified by DOI 10.1016/j.cmet.2026.07.006.
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Abstract
The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to improve cardiovascular, renal, hepatic, musculoskeletal, and organismal health. Defining dose-response relationships for weight-loss-independent mechanisms will facilitate optimization of the therapeutic potential of GLP-1 medicines.
Medical subject headings
- Glucagon-Like Peptide 1
- Weight Loss