The price of plasticity: Losing colon identity to gain metastatic potential.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42561903.
- Also identified by DOI 10.1016/j.stem.2026.07.005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The generation of highly plastic cell states in colorectal cancer that are prone to metastatic dissemination involves complex epigenetic reprogramming, rather than new genetic traits. Goto et al.<sup>1</sup> implement a serial orthotopic organoid transplantation framework to uncover the idea that losing Gata6, a guardian of the colonic lineage, promotes metastatic competence.
Medical subject headings
- Colorectal Neoplasms
- GATA6 Transcription Factor
- Colon