Living therapeutic depots: Matching design to therapeutic needs.

Zhou, Han; Liang, Qirui; Wang, Yucai · Cell Stem Cell · 2026

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Abstract

Living therapeutic depots enable localized, adaptive therapy, but their success depends on persistence, activation, and therapeutic output. Harimoto et al.<sup>1</sup> define mechanical requirements for durable bacterial containment, whereas Luo et al.<sup>2</sup> integrate transient photosynthetic hydrogen production with cardiac therapy. Together, the studies demonstrate that therapeutic needs shape living therapeutic design.

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