Filling the holes in whole genomes: A vision for personalized genomics from telomere to telomere.

Phillippy, Adam M; Mao, Yafei; Kang, Yu; Šikić, Mile; Miga, Karen H · Cell · 2026

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Abstract

Two decades after the Human Genome Project, we finally have the ability to read the complete genome of any human and (nearly) any species. These sequences provide the ideal foundation for training predictive models of the genome that will accelerate basic research, enable accurate diagnostics, and guide precision medicine.

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