Reverse transcriptases challenge the central dogma of biology, again.
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- Record sourced from PubMed, PMID 42561911.
- Also identified by DOI 10.1016/j.cell.2026.07.030.
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Abstract
In this issue of Cell, Wang et al. reveal the mechanism of a bacterial antiphage system that contains two reverse transcriptases. Through an unprecedented process, the enzymes synthesize double-stranded DNA; one uses a noncoding RNA template and the other uses its amino acid residues to template and prime DNA synthesis.
Medical subject headings
- RNA-Directed DNA Polymerase