Real-World Experience of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy.

McCrary, L Madeline; Curtis, Megan R; Kelly, Jeannie C; Elrod-Gallegos, Jessica; Kojima, Patrick; Werner, Patricia; Mullersman, Jennifer L; Habrock-Bach, Tracey et al. · Clin Infect Dis · 2026

case_series · Level IV

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Abstract

Guidelines endorse antenatal hepatitis C virus treatment following shared decision making. No clinical trial or real-world data exist for glecaprevir-pibrentasvir (GLE/PIB). We report our experience with prenatal GLE/PIB in 14 patients. Ten patients completed treatment; all achieved virologic response by or at delivery, with no maternal or neonatal safety concerns.