Why Look Further When the Solution Is in Front of You - or Is It? The Value of Confirmatory PSA in Prostate Cancer Screening.

Rannikko, Antti S; Kilpeläinen, Tuomas P; Auvinen, Anssi · Eur Urol · 2026

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Abstract

Confirmatory prostate-specific antigen measurement reclassifies many younger men below the biopsy threshold, offering a simple, low-cost way to reduce magnetic resonance imaging and biopsy. For most, reclassification means deferral rather than exclusion, and follow-up remains insufficient to rule out missed clinically significant cancers."