Clinical Spectrum and Emerging Therapeutic Approaches in Trigeminal Trophic Syndrome: Diagnostic Challenges and Pitfalls.

Nukaly, Houriah Y; Barker, Catherine S; Elston, Dirk M · J Am Acad Dermatol · 2026

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Abstract

Recognition of sensory deficits and atypical anatomic involvement can help distinguish trigeminal trophic syndrome from its common mimickers and prevent unnecessary procedures. Treatment should prioritize interruption of the itch-scratch cycle, as reconstruction alone is prone to recurrence when the underlying sensory dysfunction persists.