Protein restriction and the hallmarks of aging: A coordinated physiological adaptive response?
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- Record sourced from PubMed, PMID 42607665.
- Also identified by DOI 10.1016/j.cmet.2026.08.005.
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Abstract
Protein restriction extends lifespan across species and engages many hallmarks of aging. We propose that these diverse responses can be understood as components of a single coordinated physiological state. This response involves both cellular nutrient sensing and endocrine and neural coordination, with enhanced longevity emerging from this adaptive response.