Treatment of CCHF with supportive care, favipiravir, and avatrombopag.

Ramírez-Olivencia, Germán; Estébanez, Miriam; Mata Forte, Tatiana; Fernández Tomás, Manuel; Arce, Octavio; Sierra, Gonzalo; Sanz Alba, Marta; Simón Sacristán, María et al. · Clin Infect Dis · 2026

case_report · Level V

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Abstract

We report a severe Crimean-Congo Hemorrhagic Fever case treated with favipiravir and avatrombopag in a high-level isolation unit. This multimodal approach was associated with rapid platelet recovery, reduced transfusion requirements, and viral clearance. Combining targeted antivirals with thrombopoietin receptor agonists represents a promising strategy for managing severe CCHF coagulopathy.