New ideas about mechanism in APOL1 kidney disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 42624538.
- Also identified by DOI 10.1016/j.kint.2026.05.021.
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Abstract
Apolipoprotein L1 risk variants contribute to high rates of kidney disease among individuals of African ancestry. These gain-of-function variants cause toxicity to kidney cells, but the mechanism of injury is not clear. Many theories have been proposed, yet the field has not arrived at a consensus. Kim et al. make a compelling argument for a peroxisomal pathway of injury specifically activated under hypoxic conditions. Introducing cellular context reframes the debate about apolipoprotein L1 mechanism of disease.
Medical subject headings
- Kidney Diseases
- Apolipoproteins
- Lipoproteins, HDL
- Kidney