No staining needed: reading kidney injury by its own light.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42624540.
- Also identified by DOI 10.1016/j.kint.2026.06.017.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Proximal cells are the metabolically most active cells in the kidney and play a central role in driving kidney disease. Matsumoto et al. demonstrate that label-free near-infrared autofluorescence can visualize tubular injury in vivo by detecting coproporphyrin III accumulation caused by mitochondrial oxidative stress. The signal correlates with injury severity and treatment response in multiple mouse models and human samples, suggesting a promising biomarker for preclinical monitoring and potential clinical translation.
Medical subject headings
- Kidney Tubules, Proximal
- Acute Kidney Injury
- Optical Imaging