Structure-Function Relationship as the Foundation for Cardiac Myosin Inhibition in Hypertrophic Cardiomyopathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42663125.
- Also identified by DOI 10.1161/CIRCULATIONAHA.126.082644 and PMC identifier 13528723.
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Abstract
From bench to bedside—how basic science in myosin function and structure informed the development of precision therapy for hypertrophic cardiomyopathy ELC, essential light chain; HCM, hypertrophic cardiomyopathy; KCCQ, Kansas City Cardiomyopathy Questionnaire; LV, left ventricular; LVOT, LV outflow tract; MyBPC, myosin-binding protein C; nonobs HCM, nonobstructive hypertrophic cardiomyopathy; NT-proBNP, N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart Association Functional Classification; obs HCM, obstructive hypertrophic cardiomyopathy; RLC, regulatory light chain; S1, subfragment 1; S2, subfragment 2.