Beyond the Randle cycle: A four-nutrient model of competitive catabolism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42679792.
- Also identified by DOI 10.1016/j.cmet.2026.08.006.
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Abstract
Competitive catabolism mechanistically links increased fat mass to hyperglycemia and hyperinsulinemia. Weilandt et al. develop a differential equation model of metabolic homeostasis incorporating four circulating nutrients and insulin, which extends the framework of the Randle cycle and reveals a physiological circuit by which obesity drives type 2 diabetes.
Medical subject headings
- Models, Biological
- Diabetes Mellitus, Type 2
- Nutrients