Lactate suppresses STING activation to promote tumor immune evasion.
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- Record sourced from PubMed, PMID 42679793.
- Also identified by DOI 10.1016/j.cmet.2026.08.008.
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Abstract
Lactate, known for its metabolic functions, has recently emerged as a signaling molecule. In a recent issue of Immunity, Guo and colleagues report that lactate is a competitive antagonist of STING and propose an epidermal growth factor receptor (EGFR)-mediated signaling cascade that enhances lactate dehydrogenase A (LDHA) activity, lactate production, and immunosuppression.<sup>1</sup>.
Medical subject headings
- Membrane Proteins
- Lactic Acid
- Neoplasms
- Tumor Escape