Aging vs. biological age: Conceptual considerations for age reversal claims.

Poganik, Jesse R; Moldakozhayev, Alibek; Justice, Jamie N; Kaeberlein, Matt; Adams, Peter D; Rockwood, Kenneth; Ferrucci, Luigi; Gladyshev, Vadim N · Cell Metab · 2026

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Abstract

Whether reversal of biological age and/or aging is possible is among the most actively debated topics in the field of aging. Here, we consider the meaning of biological age reversal and its burden of proof, focusing on foundational issues and the language we use to debate these questions.

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