Metabolite buffering of labile iron governs ferroptosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42691992.
- Also identified by DOI 10.1016/j.cell.2026.07.037.
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Abstract
Iron abundance alone does not determine ferroptosis sensitivity. In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibility of labile iron, revealing an unexpected function for one of the cell's most abundant metabolite classes while raising new questions about the organization of intracellular iron metabolism.
Medical subject headings
- Ferroptosis
- Iron