Enteric glial serotonin signaling drives anti-tumor immunity in colorectal cancer.
Where this comes from
- Record sourced from PubMed, PMID 42691993.
- Also identified by DOI 10.1016/j.cell.2026.08.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Peripheral serotonergic signaling has been implicated in diverse physiological processes, yet its role in coordinating glial-immune interactions remains poorly understood. In this issue of Cell, Wen and colleagues identify enteric glial cells as critical effectors of peripheral 5-HT2AR agonism, uncovering a serotonergic neuroimmune circuit that drives cytotoxic T cell-mediated immunity against colorectal cancer.
Medical subject headings
- Colorectal Neoplasms
- Neuroglia
- Serotonin