Heart valves enter their organoid era.

Porras, Ana M; Masters, Kristyn S · Cell Stem Cell · 2026

basic_science · Level V

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Abstract

Heart valve research has long lacked accessible human model systems. In this issue of Cell Stem Cell, He et al. and Voges et al. introduce complementary stem cell-derived valve models that recreate key aspects of valve development, tissue organization, and disease, opening new avenues to investigate disease mechanisms and therapies.

Medical subject headings