Feeling the tension: Engineered stem cells convert tumor stiffness into a drug target.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42692002.
- Also identified by DOI 10.1016/j.stem.2026.08.010.
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Abstract
Radiopharmaceutical theranostics remains constrained by tumors lacking a validated molecular target. Yang et al.<sup>1</sup> engineer mesenchymal stem cells that sense tumor stiffness and respond by manufacturing a synthetic target in situ, making PET imaging and radionuclide therapy possible with existing clinical radioligands in tumors that were previously untargetable.
Medical subject headings
- Mesenchymal Stem Cells
- Neoplasms
- Cell Engineering