Discordant ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT Findings Before Radionuclide Therapy in Small Cell Lung Cancer.
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- Record sourced from PubMed, PMID 42695138.
- Also identified by DOI 10.1097/RLU.0000000000006656.
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Abstract
A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically active lesions. ⁶⁸Ga-DOTATATE PET/CT showed high SSTR expression in bone lesions and the pancreatic tail. Discordant hepatic uptake suggested tumor heterogeneity. The two scans provided complementary information on disease activity and therapeutic target expression, supporting patient selection and individualized planning for an SSTR-targeted radionuclide therapy-based comprehensive treatment strategy.