The widening medication adherence gap.

Marcum, Zachary A · PLoS Med · 2026

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Abstract

The gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. Closing this gap requires more than individual behavior change; it requires system-level solutions, including coverage and funding design, pharmacist-led programs, and health information technology.

Medical subject headings