Ultrasound Captured-Nanomachine for Restarting Healthy Renal Function.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42706803.
- Also identified by DOI 10.1002/adhm.71695.
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Abstract
Acute kidney injury (AKI) was a common clinical emergency with serious complications, and its treatment remains challenging. Here, we designed a biocompatible, ultrasound-captured nanomachine (NTMCH) that proactively delivered carbon monoxide (CO) under ultrasound. This system achieved kidney protection and enhanced renal clearance in a mouse model of AKI. The nanomachine was fabricated by coating niobium on one side of amine-functionalized mesoporous TiO<sub>2</sub>, followed by dimanganese decacarbonyl (Mn<sub>2</sub>(CO)<sub>10</sub>) loading and hyaluronic acid modification. Asymmetric CO release both propelled the nanomachine and acted as a therapeutic gas. At the kidney injury site, ultrasound triggers CO release, which stimulates ROS generation from mesoporous titanium dioxide (MTD), cascading Mn<sub>2</sub>(CO)<sub>10</sub> activation. This enhanced CO diffusion and renal clearance in synergy with Nb. This ultrasound-responsive nanomachine offered outstanding potential for kidney protection via CD44 regulation, with findings that could advance future clinical development.