Relationship between methicillin-resistant Staphylococcus aureus nasal carriage and surgical site infection after hepatectomy.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 42710258.
- Also identified by DOI 10.1016/j.surg.2026.110537.
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Abstract
Nasal carriage of methicillin-resistant Staphylococcus aureus is associated with an increased risk of postoperative surgical site infection. However, there are no definitive recommendations regarding preoperative methicillin-resistant Staphylococcus aureus screening or decolonization protocols in patients undergoing hepatectomy. This study investigated the relationship between nasal methicillin-resistant Staphylococcus aureus carriage and postoperative methicillin-resistant Staphylococcus aureus-related surgical site infections following hepatectomy. This retrospective cohort study included 603 consecutive patients who underwent hepatectomy between January 2011 and December 2025, classified into methicillin-resistant Staphylococcus aureus-positive and -negative groups based on nasal polymerase chain reaction results. Between-group incidence of surgical site infections and postoperative methicillin-resistant Staphylococcus aureus infections was compared. Methicillin-resistant Staphylococcus aureus nasal carriage was identified in 33 patients (5.5%). The incidence of surgical site infections was 30.3% and 13.0% in the methicillin-resistant Staphylococcus aureus-positive and -negative groups (P = .016). Among surgical site infection cases, the frequency of methicillin-resistant Staphylococcus aureus infection was significantly higher in the methicillin-resistant Staphylococcus aureus-positive group (70.0%) than in the methicillin-resistant Staphylococcus aureus-negative group (2.7%) (P < .001). Nasal methicillin-resistant Staphylococcus aureus colonization was associated with an increased risk of postoperative surgical site infection-overall and methicillin-resistant Staphylococcus aureus related-following hepatectomy. Targeted preoperative screening may help reduce the incidence of methicillin-resistant Staphylococcus aureus surgical site infections in this patient population.