Historical perspective on evolution of neuraxial delivery for pain (1975-2025).

Yaksh, Tony; Hayek, Salim Michel · Reg Anesth Pain Med · 2026

editorial · Level V

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Abstract

In the present commentary, we consider the historical trajectory that reflects the evolution of neuraxial therapeutics that has transpired over the last 50 or so years, with a particular emphasis on its application to pain and its management. The review addresses the advances that led to where we are now in the 21st century with neuraxially targeted therapeutics and consideration of where this thread leads.

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