A conversation on human brain clearance.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 42711338.
- Also identified by DOI 10.1038/s41467-026-77138-3 and PMC identifier 13554049.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Brain clearance is essential for eliminating metabolic byproducts and macromolecules to maintain brain homeostasis. In this Q&A, four experts share their views on how the brain clears waste products, why these clearance pathways are essential for maintaining brain health, and how their dysfunction may contribute to neurological diseases. The discussion explores current imaging approaches, key measurement challenges, methodological limitations, and emerging technologies that could improve our understanding of brain clearance in humans as well as diagnosis, monitoring, and treatment of brain disorders.