Hyperpolarized [1-13C]-Pyruvate MRI Differentiates Benign Fibroma From High-grade Serous Carcinoma.
case_series · Level IV
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- Also identified by DOI 10.1097/RLU.0000000000006625.
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Abstract
Hyperpolarized [1-13C]pyruvate MRI enables real-time assessment of tumor glycolytic flux. We report 2 women with suspected ovarian cancer examined preoperatively with hyperpolarized [1-13C]-pyruvate MRI and FDG PET/CT. In a 49-year-old woman with a right adnexal mass, FDG uptake was limited, and hyperpolarized imaging demonstrated minimal lactate production; histopathology revealed a benign fibroma. In a 51-year-old woman with advanced disease, FDG PET/CT showed extensive metabolically active tumors. Hyperpolarized imaging demonstrated markedly increased lactate-to-pyruvate conversion within solid tumor components. Histopathology confirmed high-grade serous carcinoma. These cases illustrate the potential complementary role of hyperpolarized [1-13C]pyruvate MRI in differentiating benign from malignant adnexal masses.
Medical subject headings
- Magnetic Resonance Imaging
- Fibroma
- Pyruvic Acid
- Ovarian Neoplasms