Nasolabial Flap in Oncologic Oral Cavity Reconstruction: A Systematic Review and Meta-Analysis.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 42728624.
- Also identified by DOI 10.1002/lary.70910.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To systematically evaluate the outcomes of nasolabial flap (NSFL) reconstruction for oncologic oral cavity defects. A systematic review and meta-analysis was performed and reported in accordance with the PRISMA statement. PubMed/MEDLINE, Cochrane Library, Scopus, Embase, and Google Scholar were searched for studies published between 1990 and 2026. Studies reporting NSFL reconstruction following oncologic resection of oral cavity defects were included. Single-arm pooled proportions were calculated using random-effects models. Risk of bias, sensitivity analyses, funnel plot, and Egger regression tests were used to assess methodological quality, robustness, and potential publication bias. Twenty-five studies comprising 827 patients were included in the qualitative synthesis, of which 23 contributed to the quantitative analysis. Pooled flap necrosis was 3.4% (95% CI, 1.6-7.1), overall complications 9.2% (95% CI, 4.9-16.4), and donor-site morbidity 0.9% (95% CI, 0.2-4.3). Functional and aesthetic outcomes were generally favorable. The NSFL represents a reliable reconstructive option for selected small- to medium-sized oncologic oral cavity defects, with low rates of flap-related complications and donor-site morbidity.