A Barrier Betrayed: Hillock in Lung Squamous Cell Carcinoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42740576.
- Also identified by DOI 10.1158/0008-5472.CAN-26-2945.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Airway hillocks are specialized, stratified squamous epithelial structures featuring luminal barrier cells supported by a dedicated basal stem cell population. In this issue of Cancer Research, Izzo and colleagues identify a distinct population of slow-cycling KRT13+ hillock-like tumor cells in lung squamous cell carcinoma, a cell state conserved across multiple squamous cell carcinoma (SCC) models. Mechanistically, KLF4 drives KRT13 expression, correlating with enrichment of potential therapeutic targets and resistance to platinum-based chemotherapy. By linking the physiologic epithelial barrier to therapeutic resistance, this study unlocks a previously uncharacterized mechanism underlying SCC biology. See related article by Izzo et al., p. 4472.
Medical subject headings
- Carcinoma, Squamous Cell
- Lung Neoplasms