Two-year outcomes following PSMA PET and MRI guided prostate SABR with simultaneous focal boost: a brief report from the ARGOS-CLIMBER phase 1/2 trial.

Alayed, Yasir; Loblaw, Andrew; Mendez, Lucas C; Correa, Rohann J M; Dhar, Aneesh; Laidley, David; Warner, Andrew; Fakir, Hatim et al. · Radiother Oncol · 2026

rct · Level II

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Abstract

ARGOS-CLIMBER is a phase 1/2 trial evaluating PSMA PET and MRI guided prostate SABR with a simultaneous boost to intraprostatic and nodal disease in men with unfavourable intermediate and high-risk prostate cancer. The updated results demonstrate acceptable safety and quality of life with high biochemical and imaging response rates.