Extensive Neurolymphomatosis as the Sole Site of Relapse in Mantle Cell Lymphoma.

Cui, Futao; Liu, Yunyi; Tian, Rong; Xiao, Liu · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Neurolymphomatosis associated with mantle cell lymphoma (MCL) is extremely rare. Thus, we report a case of imaging findings of neurolymphomatosis in a 60-year-old man with MCL who developed acute neurological symptoms after complete remission. On 18F-FDG PET/CT and brain PET/MR, it presents as multiple spinal root or nerve enlargement with intense FDG uptake. The final diagnosis confirmed recurrent neurolymphomatosis of MCL.