Association of diffuse idiopathic skeletal hyperostosis with postoperative outcomes following surgery for degenerative lumbar spine disease.

Abstract

To determine whether diffuse idiopathic skeletal hyperostosis (DISH), particularly when extending into the lumbar spine (L-DISH), is associated with postoperative outcomes after surgery for degenerative lumbar disease. Multiple bibliographic, trial, and Japanese literature databases were searched from inception through June 30, 2026. Comparative DISH or L-DISH studies and within-DISH prognostic or surgical-strategy studies were eligible. Decompression and short-segment interbody fusion evidence were analyzed separately, and overlapping cohorts were resolved for each outcome. Study-specific adjusted estimates were prioritized for inference. Crude risk ratios (RRs) from unadjusted event counts were retained only as secondary, illustrative k = 2 syntheses. Risk of bias was assessed at the result level, and certainty was graded by outcome. Fifteen reports representing 12 independent studies, all retrospective and from Japan, were included. Adjusted study-specific associations for reoperation pointed toward higher risk with DISH/L-DISH after short-segment fusion (hazard ratio [HR], 5.46; 95% confidence interval [CI], 2.25-13.30), mixed lumbar procedures (HR, 2.049; 95% CI, 1.199-3.503), and decompression (HR, 3.37; 95% CI, 1.31-8.69), but effect measures, adjustment sets, and time horizons differed and were not pooled. Secondary crude syntheses contained only 2 cohorts each: decompression RR, 2.50 (95% CI, 1.53-4.08), and fusion RR, 3.93 (95% CI, 2.00-7.70). Modified Hartung-Knapp intervals were 0.10-60.12 and 0.05-310.05, respectively. Radiographic nonunion or pseudarthrosis estimates differed markedly (RR, 12.44; 95% CI, 4.39-35.32; and RR, 1.75; 95% CI, 1.07-2.88) and were not pooled. Certainty was very low. Primary adjusted associations and supportive crude observational estimates were directionally consistent with greater reoperation risk, but sparse data, incomplete confounding control, time-dependent outcome handling, and an exclusively Japanese evidence base make the magnitude uncertain and limit transportability. DISH/L-DISH may be regarded as a possible risk marker, not a causal determinant or a basis for a universal operative strategy. CRD420261454437.