Effects of L-thyroxine on serum lipid profiles in infants with congenital hypothyroidism.
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Abstract
Serum lipid profiles and the effects of thyroid hormone on them were studied in infants with congenital hypothyroidism. Serum total cholesterol, high-density lipoprotein cholesterol (HDLC), and low-density lipoprotein cholesterol levels were increased in infants with hypothyroidism;L-thyroxine therapy decreased the HDLC levels, leading to a reduction in serum concentrations of total cholesterol. It appears that thyroid hormone suppresses circulating HDLC, although the mechanism was not discovered in this study.
Medical subject headings
- Congenital Hypothyroidism
- Lipids
- Thyroxine