Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
basic_science · Level V
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- Record sourced from PubMed, PMID 7479885.
- Also identified by PMC identifier 40698.
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Abstract
The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.
Medical subject headings
- Chromosome Mapping
- DNA-Binding Proteins
- Mice, SCID
- Mutation
- Protein Serine-Threonine Kinases
- Severe Combined Immunodeficiency