Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.
basic_science · Level V
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- Record sourced from PubMed, PMID 7479899.
- Also identified by PMC identifier 40531.
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Abstract
Sin4 and Rgr1 proteins, previously shown by genetic studies to play both positive and negative roles in the transcriptional regulation of many genes, are identified here as components of mediator and RNA polymerase II holoenzyme complexes. Results with Sin4 deletion and Rgr1 truncation strains indicate the association of these proteins in a subcomplex comprising Sin4, Rgr1, Gal11, and a 50-kDa polypeptide. Taken together with the previous genetic evidence, our findings point to a role of the mediator in repression as well as in transcriptional activation.
Medical subject headings
- Fungal Proteins
- RNA Polymerase II
- Repressor Proteins
- Saccharomyces cerevisiae Proteins
- Trans-Activators
- Transcription Factors