Prelabeling of chimeric monoclonal antibody L6 with 90yttrium- and 111indium-1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA) chelates for radioimmunodiagnosis and therapy.
basic_science · Level V
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Abstract
90Y and 111In have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate). The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody. Studies in human patients showed excellent 111In single-photon emission computed tomography images of breast cancer lesions 24 h after injection.
Medical subject headings
- Antibodies, Monoclonal
- Antibodies, Neoplasm
- Breast Neoplasms
- Heterocyclic Compounds, 1-Ring
- Indium Radioisotopes
- Isotope Labeling
- Radioimmunotherapy
- Yttrium Radioisotopes