Humoral and cellular activation in a simulated extracorporeal circuit.
basic_science · Level V
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Abstract
Endothelial injury consequent upon widespread humoral and cellular activation is probably a major contributor to the phenomenon of cardiopulmonary bypass-induced organ dysfunction. This article reviews some of the mechanisms by which complement and neutrophil activation and interleukin-8 may be involved in this inflammatory response. In a model consisting of a simulated extracorporeal circulation we were able to demonstrate complement activation, profound and specific changes in neutrophil adhesion molecule expression, and interleukin-8 generation. The importance of these changes and their potential interactions are discussed.
Medical subject headings
- Antibody Formation
- Extracorporeal Circulation
- Immunity, Cellular
- Models, Cardiovascular