First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.
case_report · Level V
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- Record sourced from PubMed, PMID 7507240.
- Also identified by PMC identifier 2399942.
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Abstract
Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils.
Medical subject headings
- Agranulocytosis
- Chlorpromazine
- Granulocyte Colony-Stimulating Factor