T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis.
basic_science · Level V
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Abstract
Encounters with antigen can stimulate T cells to become activated and proliferate, become nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to interleukin-2-stimulated cell cycling and T cell receptor reengagement at high antigen doses. This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells. This mechanism deleted autoreactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein.
Medical subject headings
- Antigens
- CD4-Positive T-Lymphocytes
- Encephalomyelitis, Autoimmune, Experimental
- Immune Tolerance
- T-Lymphocytes